Following treatment with clarithromycin, 400 mg daily for 4 weeks, significant improvements in mucociliary clearance, volume of secretions, cough frequency, and dyspnea-on-exertion were documented in 32 patients with sinobron-chial syndrome. Low-dose roxithromycin (Rulid; Albert-Roussel Pharma GmbH; Wiesbaden, Germany) was shown to significantly improve the aeration of all four sinuses and to significantly reduce neutrophil and IL-8 levels in the nasal […]

Between 1990 and 1992, sinusitis-associated symptoms resulted in > 70 million days of restricted activity. The economic impact of the disease is also staggering, with health-care expenditures in the United States attributable to sinusitis estimated to be about $5.8 billion annually. Nasal congestion, increased quantity and tenacity of secretions, facial pain, and fatigue are common among patients with chronic sinusitis. […]

Preliminary data from studies of patients with COPD have shown improvements in symptom scores and FEV1 after macrolide treatment. As biological response modifiers, macrolides have the potential to improve the outcomes of patients with inflammatory airway diseases. Large scale, placebo-controlled clinical trials designed to assess long-term efficacy and safety in these diseases are warranted. Key words: anti-inflammatory activity; asthma; […]

DNA Transfection and Luciferase Assay The plasmid NF-kB containing the luciferase coding sequence under the control of NF-kB was kindly supplied by Dr. S. Roman. Cells were seeded at a cell density of 104 cells per well in 96-well plates and were transfected on the following day with plasmid NF-kB (Lipofectamine 2000; Invitrogen SA; Izasa Barcelona, Spain). To […]

We hypothesized that the antiinflammatory activity would be an important component of the therapeutic effect of TEL on respiratory infections. Thus, we designed the present study to test the antiinflammatory activity of TEL in an in vitro model of LPS-induced airway inflammation, and to determine whether this antiinflammatory activity occurs in vivo, in a mouse model of acute, LPS-induced […]

Conclusions: We have provided evidence that TEL exerts potent antiinflammatory effects in LPS-induced airways injury. We propose that TEL acts in the early phase of inflammation by reducing the release of inflammatory mediators through NF-kB inhibition, and in the later phase through enhancement of inflammatory cell apoptosis. Key words: airway inflammation; antiinflammatory activity; apoptosis; macrophage inflammatory protein-2; […]

Levitra 20 mg comes in the form of film-coated tablets. Each pack contains 2, 4, 8 or 12 tablets. Levitra is a drug used for treatment for erectile dysfunction (ED) in men – the medical name itself, vardenafil, suggests that it is used against difficulties in getting or maintaining an erection. At least one in […]